Frequencies of genetic polymorphisms in genes encoding for biotransformation enzymes in patients with Crohn’s disease and controls
| Genetic polymorphism | No of patients (%) | No of controls (%) | Odds ratio | 95% CI |
|---|---|---|---|---|
| CYP1A1, cytochrome P450 1A1; GSTM1, glutathione S-transferase mu-1; GSTT1, glutathione S- transferase theta-1; GSTP1, glutathione S-transferase pi-1; EPXH, microsomal epoxide hydrolase; Ile, isoleucine; Val, valine; Tyr, tyrosine; His, histidine; Arg, arginine; 95% CI, 95% confidence interval. | ||||
| *2×3 table, χ2=23.7; p<0.0001. | ||||
| CYP1A1 (3′-flanking region) | ||||
| T/T | 130 (86) | 125 (84) | ||
| T/C | 20 (13) | 24 (16) | 0.87 | 0.30–2.49 |
| C/C | 1 (1) | 0 (0) | ||
| CYP1A1 (exon7) | ||||
| Ile/Ile | 129 (86) | 122 (82) | ||
| Ile/Val | 20 (13) | 22 (15) | 0.70 | 0.27–1.83 |
| Val/Val | 2 (1) | 5 (3) | ||
| GSTM1 | ||||
| Wild-type | 69 (46) | 75 (50) | 1.17 | 0.67–2.05 |
| Deletion | 82 (54) | 74 (50) | ||
| GSTT1 | ||||
| Wild-type | 128 (85) | 119 (80) | 0.71 | 0.34–1.47 |
| Deletion | 23 (15) | 30 (20) | ||
| GSTP1 | ||||
| Ile/Ile | 75 (49) | 87 (58) | ||
| Ile/Val | 63 (42) | 55 (37) | 1.37 | 0.72–2.58 |
| Val/Val | 13 (9) | 7 (5) | ||
| EPXH (exon 3) | ||||
| His/His | 20 (13) | 59 (40) | ||
| Tyr/His | 60 (40) | 58 (39) | 2.92* | 1.64–5.20 |
| Tyr/Tyr | 71 (47) | 32 (21) | ||
| EPXH (exon 4) | ||||
| His/His | 90 (60) | 98 (66) | ||
| His/Arg | 53 (35) | 48 (32) | 1.36 | 0.68–2.72 |
| Arg/Arg | 8 (5) | 3 (2) | ||