Interleukin 10 (IL-10) (−1082) polymorphism allele and genotype distribution
| IBS (n=230) | Controls (n=450) | |||
|---|---|---|---|---|
| n | % | n | % | |
| *Odds ratio (OR) 1.17 (95% confidence interval 0.93–1.49); p=0.097. | ||||
| †Fewer irritable bowel syndrome (IBS) patients of high producer (G/G) genotype (χ2=11.97, df=2, p=0.003), with more patients carrying A allele (A+: G/A or A/A) (χ2=8.08, OR 1.72 (1.18–2.50), p=0.004)‡. | ||||
| §n= number of alleles in each group, being twice the number of individuals as two alleles are inherited. | ||||
| ¶n=number of individuals with specific genotype. | ||||
| IL-10 | ||||
| Allele frequency§ | ||||
| −1082*G (high) | 219 | 48* | 438 | 52 |
| −1082*A (low) | 241 | 52 | 412 | 48 |
| Genotype¶ | ||||
| G/G (high producer) | 49 | 21† | 135 | 32 |
| G/A (intermediate) | 121 | 53 | 168 | 39 |
| A/A (low producer) | 60 | 26 | 122 | 29 |
| Genotype¶ | ||||
| A− (G/G) | 49 | 21‡ | 135 | 32 |
| A+ (A/A or G/A) | 181 | 79 | 290 | 68 |