Association testing based on the haplotype frequencies of A→G1364, A→C2607, and DEL2609
| Group | n* | ln(L) | χ2 | p† |
|---|---|---|---|---|
| *Number of individuals. | ||||
| †The relevant test statistic is T= ln(L, cases) + ln(L, controls) − ln(L, cases+controls together). Twice this value has an approximate χ2 distribution with a number of degrees of freedom (df) equal to the number of haplotypes estimated. For the above data: (−90.84) + (−97.86) − (−192.24) = 3.54; χ2=2×3.54 = 7.08 which on 7 df is associated with an empirical significance level of p=0.42. | ||||
| Patients | 91 | −90.84 | 36.54 | 0.42 |
| Controls | 71 | −97.86 | 21.99 | |
| All subjects | 162 | −192.24 | 56.49 | |