Odds ratios (ORs) with 95% confidence intervals (CIs) for the risk of having small, medium, or large adenomas by familial history of colorectal cancer (FHCRC) and other cancers (FHOC) in first degree relatives
| Adenoma cases (n) | Healthy controls* (n) | Crude OR (95% CI) | Adjusted† OR (95% CI) | Adjusted‡ OR (95% CI) | |
|---|---|---|---|---|---|
| *The healthy controls were sex (50% men) and age matched (±5 years) to cases and proven to be free of polyps by colonoscopy. | |||||
| †Adjusted for smoking status. | |||||
| ‡Adjusted for smoking status and intake of alcohol (g/day). | |||||
| Occurrence of small sized adenomas (maximum diameter <5 mm) | |||||
| FHCRC | |||||
| No | 11 | 29 | 1.0 | 1.0 | 1.0 |
| Yes | 3 | 6 | 1.3 (0.3–6.2) | 1.5 (0.3–7.8) | 1.6 (0.3–8.1) |
| FHOC | |||||
| No | 9 | 23 | 1.0 | 1.0 | 1.0 |
| Yes | 5 | 12 | 1.1 (0.3–3.9) | 0.9 (0.2–3.9) | 0.9 (0.2–3.7) |
| Occurrence of medium sized adenomas (maximal diameter 5–9 mm) | |||||
| FHCRC | |||||
| No | 33 | 29 | 1.0 | 1.0 | 1.0 |
| Yes | 7 | 6 | 1.1 (0.3–3.4) | 1.2 (0.3–4.2) | 1.2 (0.3–4.2) |
| FHOC | |||||
| No | 23 | 23 | 1.0 | 1.0 | 1.0 |
| Yes | 17 | 12 | 1.4 (0.6–3.6) | 1.8 (0.6–4.9) | 1.8 (0.6–4.9) |
| Occurrence of large sized adenomas (maximum diameter ≥10 mm) | |||||
| FHCRC | |||||
| No | 29 | 29 | 1.0 | 1.0 | 1.0 |
| Yes | 4 | 6 | 0.7 (0.2–2.6) | 0.6 (0.1–2.4) | 0.6 (0.2–2.5) |
| FHOC | |||||
| No | 18 | 23 | 1.0 | 1.0 | 1.0 |
| Yes | 15 | 12 | 1.6 (0.6–4.3) | 1.5 (0.5–4.0) | 1.4 (0.5–3.8) |