Comparison of body mass, liver enzymes, C reactive protein, testosterone, and cytokine levels in the rat models at baseline and at 16 weeks
| Baseline | Week 16 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SC | PPVL | PSS | p Value SC v PPVL | p Value SC v PSS | SC | PPVL | PSS | p Value SC v PPVL | p Value SC v PSS | |
| SC, sham operated surgical controls; PPVL, partial portal vein ligation; PSS, portasystemic shunting; ALP, alkaline phosphatase; ALT, alanine aminotransferase; 25-OH vit D, 25-hydroxy vitamin D; CRP, C reactive protein; TNF-α, tumour necrosis factor α; IL, interleukin. | ||||||||||
| Body mass (g) | 320.15 (57.35) | 301.56 (83.72) | 320.15 (57.35) | 0.567 | 1.0 | 392.4 (101.9) | 414.4 (92.5) | 226.6 (54.66) | 0.63 | <0.001 |
| Albumin (g/l) | 17.78 (1.19) | 17.57 (0.62) | 18.22 (1.44) | 0.68 | 0.42 | 16.78 (1.48) | 14.86 (1.68) | 13.33 (1.12) | 0.03 | <0.001 |
| ALP (IU/l) | 281.67 (33.49) | 284.86 (33.49) | 321.89 (76.41) | 0.9 | 0.23 | 184.89 (30.72) | 335.43 (106.79) | 650.11 (130.28) | <0.001 | <0.001 |
| ALT (IU/l) | 59.22 (14.06) | 47.57 (5.19) | 67.0 (9.15) | 0.06 | 0.18 | 58.56 (8.65) | 116.43 (47.19) | 121.11 (33.72) | <0.001 | <0.001 |
| CRP (mg/l) | 30.89 (4.26) | 28.56 (3.51) | 33.56 (5.29) | 0.26 | 0.26 | 26.44 (3.28) | 29.71 (4.96) | 33.11 (1.69) | 0.13 | <0.001 |
| Testosterone (pg/ml) | 16.48 (10.55) | 13.53 (5.92) | 13.7 (7.17) | 0.59 | 0.58 | 10.11 (3.55) | 14.24 (10.84) | 3.43 (0.96) | 0.4 | <0.001 |
| 25-OH vitD (ng/ml) | 29.23 (3.29) | 27.16 (2.84) | 25.97 (3.07) | 0.23 | 0.09 | 23.03 (4.47) | 22.93 (2.07) | 10.14 (2.0) | 0.89 | <0.001 |
| IL-1 (pg/ml) | 27.84 (14.73) | 39.57 (17.24) | 38.92 (13.49) | 0.14 | 0.3 | 31.73 (19.18) | 29.03 (13.02) | 39.53 (18.72) | 0.76 | 0.56 |
| IL-6 (pg/ml) | 9.95 (7.9) | 12.3 (7.42) | 5.71 (3.78) | 0.55 | 0.16 | 11.05 (7.61) | 10.6 (3.94) | 7.4 (2.28) | 0.89 | 0.28 |
| TNF-α (pg/ml) | 58.99 (10.3) | 67.7 (11.78) | 64.71 (12.64) | 0.13 | 0.27 | 68.13 (13.44) | 67.77 (19.17) | 99.63 (29.18) | 0.93 | <0.001 |