Univariate and multivariate logistic regression analyses of factors associated with advanced liver fibrosis (stages 3 and 4) in both HCV monoinfected and HIV-HCV coinfected patients combined
| Factor | Univariate, OR (95% CI) | p Value | Multivariate, OR (95%CI) | p Value |
|---|---|---|---|---|
| HIV, human immunodeficiency virus; HCV, hepatitis C virus; IDU, injecting drug use; ALT, alanine aminotransferase; OR, odds ratio. | ||||
| *Data also analysed in the model as continuous variable and did not show significant association. | ||||
| †Upper limit of normal for ALT is 55 IU/l | ||||
| ‡ Data were analysed using different categories and did not show a significant association. | ||||
| Age at HCV infection* (y) | ||||
| ⩽22 (ref) | 1 | |||
| >22 | 0.91 (0.51–1.61) | 0.818 | — | — |
| Sex | ||||
| Female (ref) | 1 | |||
| Male | 0.93 (0.50–1.86) | 0.838 | — | — |
| Route of HCV transmission | ||||
| Transfusion (ref) | 1 | |||
| IDU | 1.25 (0.61–2.39) | 0.509 | — | — |
| HIV positivity | 2.68 (1.40–5.12) | 0.003 | 2.88 (1.65–6.19) | 0.004 |
| Duration of HCV (y) | ||||
| ⩽15 (ref) | 1 | |||
| >15 | 4.67 (2.52–8.83) | <0.0001 | 4.07 (2.17–7.77) | <0.0001 |
| ALT (IU/l)† | ||||
| ⩽ 80 (ref) | 1 | |||
| > 80 | 2.96 (1.63–5.37) | <0.0001 | 3.20 (1.65–6.19) | 0.001 |
| Alcohol (units/week)‡ | ||||
| ⩽20 (ref) | 1 | |||
| >20 | 1.31 (0.77–2.65) | 0.382 | — | — |
| Genotype | ||||
| 2, 3, 4 (ref) | 1 | |||
| 1 | 1.16 (0.54–2.57) | 0.669 | — | — |