Groupa | −7 days | Time 0b | 2 hb | 6 h | 24 hb | 48 hb |
---|---|---|---|---|---|---|
Results are given as mean (SD). | ||||||
aTZP, tazobactam-piperacillin 120 mg/kg; IB-367 1 mg/kg. | ||||||
Each measurement refers to: b20 animals; c13 animals; dseven animals; esix animals; f15 animals; g10 animals; hnine animals; i18 animals. | ||||||
*p<0.05 versus BDL placebo and TZP treated animals. | ||||||
Sham placebo | ≤0.05 | 0.08 (0.02) | 1.12 (0.45) | 0.26 (0.07)b | ≤0.05b | ≤0.05b |
Sham TZP | ≤0.05 | 0.09 (0.02) | 0.98 (0.22) | 0.31 (0.08)b | ≤0.05b | ≤0.05b |
Sham IB-367 | ≤0.05 | 0.07 (0.02) | 0.43 (0.16) | 0.13 (0.05)b | ≤0.05b | ≤0.05b |
BDL placebo | ≤0.05 | 0.12 (0.03) | 4.65 (1.14) | 0.91 (0.19)c | 0.13 (0.03)d | 0.11 (0.02)e |
BDL TZP | ≤0.05 | 0.12 (0.03) | 4.87 (1.39) | 0.82 (0.21)f | 0.14 (0.04)g | 0.12 (0.03)h |
BDL IB-367 | ≤0.05 | 0.09 (0.03) | 0.78 (0.22) | 0.18 (0.04) i* | 0.06 (0.01)i* | 0.07 (0.02)i |