Demographic, virological, biochemical, and histological characteristics of the 114 non-responders according to the group assigned for re-treatment
| Group A (IFN+riba) | Group B (IFN+riba) | Group C (IFN+riba+ama) | |
|---|---|---|---|
| IFN, interferon; riba , ribavirin; HCV, hepatitis C virus; ALT, alanine aminotransferase; HAI, histological activity index. | |||
| No of patients | 44 | 46 | 24 |
| Sex (male) | 29 (66%) | 31 (67%) | 16 (68%) |
| Age (y) (median (range)) | 51 (32–59) | 51 (30–60) | 50 (30–59) |
| ALT (UI/l) (median (range)) | 103 (60–240) | 98 (62–308) | 105 (64–284) |
| HCV RNA (eq/ml×106) (median (range)) | 2.8 (0.6–21.5) | 3.0 (0.7–18.4) | 3.2 (0.8–28.6) |
| HCV genotype 1 | 31 (70%) | 33 (72%) | 17 (71%) |
| HAI (median (range)) | 5.6 (4–10) | 5.3 (4–9) | 5.4 (4.10) |
| Cirrhosis | 11 (25%) | 12 (26%) | 8 (33%) |
| Previous interferon treatment | |||
| Dose (MU) (median (range)) | 287 (252–432) | 284 (264–504) | 286 (260–432) |