Effect of taurolithocholate (TLC) treatment on the intrinsic transfer rates derived from bicompartmental analysis of plasma decay of 14C-taurocholate (TC)†
| Intrinsic transfer rates‡ (/min) | |||
|---|---|---|---|
| r12 | r21 | r3 | |
| †Values are mean (SEM) for five animals per group. | |||
| ‡The fractional transfer rates derived from the compartmental analysis of 14C-TC plasma decay, r12 (uptake), r21 (plasma reflux), and r3 (canalicular excretion), were obtained according to standard equations for an open bicompartmental model (Richards’ model). | |||
| **p<0.005 compared with the control group. | |||
| Control | 1.108 (0.056) | 0.071 (0.008) | 0.137 (0.013) |
| TLC | 1.285 (0.108) | 0.139 (0.016)** | 0.058 (0.008)** |