Clinical recurrence and outcome in the four patients in whom histological recurrence was diagnosed in protocol biopsies
| Patient (OLT) | Delay post-OLT (y) | Liver enzyme titre (ALT (IU/l)) (N<43) | Autoantibody titre | Histological features | Treatment |
|---|---|---|---|---|---|
| FK, tacrolimus; OLT, orthotopic liver tranplantation; ALT, alanine aminotransferase; ANA, antinuclear antibodies; SMA, smooth muscle antibodies; SLA, soluble liver antigen. | |||||
| 51 | 15 | 1000 | ANA=1:640, anti-SMA=1:160, anti-SLA− | Substantial portal inflammatory plasmocyte infiltration, moderate septal fibrosis | Switch to FK* |
| 155 | 10 | 80 | SMA=1:640, anti-SLA+ | Substantial plasmocyte infiltration in portal tract | Higher dose resumption of steroid therapy |
| 205 | 11 | 182 | SMA=1:640, anti-SLA− | Moderate plasmocyte infiltration in portal tract | Higher dose resumption of steroid therapy |
| 421 | 10 | 680 | SMA=1:320, anti-SLA− | Substantial portal inflammatory plasmocyte infiltration, scant areas of lobular necrosis | Switch to FK* and retransplantation |