Mongolian gerbils infected at 14 weeks of age | Mongolian gerbils infected at 5 weeks of age | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Criteria | ATCC 43504 (n=3) | TN2GF4 (n=6) | K-6 (n=4) | Control (n=4) | p Value* | ATCC 43504 (n=5) | TN2GF4 (n=4) | K-6 (n=5) | Control (n=6) | p Value* |
*The Kruskal-Wallis test was used for comparisons between the four groups. | ||||||||||
†Bacterial counts were expressed as log10 colony forming units (CFU)/gastric wall (mean (SD)). | ||||||||||
‡p<0.05 for a bacterial strain group compared with uninfected controls (Fisher’s exact test). | ||||||||||
OD, optical density. | ||||||||||
Bacterial counts† | 5.2 (0.3) | 5.0 (0.7) | 5.7 (1.2) | N.D. | 0.174 | 5.7 (1.2) | 4.8 (0.2) | 4.4 (0.10) | ND | 0.071 |
Culture positive | 2/3 | 5/6 | 2/4 | 0/4 | 3/5 | 3/4 | 3/5 | 0/6 | ||
Histological results | 3/3 | 6/6 | 4/4 | 0/4 | 0.017 | 5/5 | 4/4 | 4/5 | 0/6 | 0.025 |
IgG titres (OD450) | ||||||||||
Mean (SD) | 0.37 (0.12) | 0.46 (0.32) | 0.17 (0.15) | 0.05 (0.02) | 0.017 | 0.44 (0.37) | 0.33 (0.31) | 0.16 (0.20) | 0.04 (0.01) | 0.025 |
Response (>0.1) | 3/3 | 6/6 | 4/4 | 0/4 | 5/5 | 4/4 | 4/5 | 0/6 | ||
Infection rate (%) | 100‡ | 100‡ | 100‡ | 0 | 100‡ | 100‡ | 80‡ | 0 |