Significance CD subgroup v controls | ||||
---|---|---|---|---|
Group | No of individuals | IBD5 risk haplotype (H2) frequency | p Value | RR (95%CI) |
p values in bold are significant (p<0.05) after application of Bonferroni correction factor of 24 (3 phenotypes×8 haplotypes tested for association). | ||||
CD, Crohn’s disease; IBD, inflammatory bowel disease; RR, relative risk. | ||||
All CD | 330 | 46.8 | 0.0004 | 1.4 (1.2–1.7) |
Perianal CD | 144 | 52.1 | <0.0001 | 1.7 (1.3–2.2) |
No perianal CD | 186 | 42.2 | — | — |
Perianal CD only | 9 | 50.0 | — | — |
Ileal CD | 255 | 47.3 | 0.0007 | 1.4 (1.2–1.7). |
Ileal and no perianal CD | 148 | 42.9 | — | — |
Ileal CD only | 74 | 38.5 | — | — |
Colonic CD | 201 | 44.3 | — | — |
Colonic and no perianal CD | 112 | 39.3 | — | — |
Colonic CD only | 23 | 48.7 | — | — |
Controls | 870 | 38.9 | — | — |