Effects of [D-Lys-3]-GHRP-6 administered intraperitoneally (20–200 nmol/mouse every 12 hours for six days) on food intake, epididymal fat mass, gastrocnemius muscle, and blood glucose, insulin, cholesterol, triglyceride, and free fatty acid concentrations in ob/ob obese mice
| Saline | 20 nmol | 200 nmol | |
|---|---|---|---|
| *p<0.05, **p<0.01 compared with physiological saline treated controls. | |||
| Food intake (g/day) | 4.845 (0.160) | 4.527 (0.261) | 4.285 (0.298) |
| Fat pad mass (g) | 0.974 (0.066) | 0.897 (0.169) | 0.860 (0.086) |
| Skeletal muscle (g) | 0.300 (0.012) | 0.314 (0.009) | 0.326 (0.013) |
| Glucose (mmolli) | 13.01 (1.538) | 12.06 (1.549) | 7.489 (1.081)* |
| Insulin (pmol/1) | 8294 (1676) | 6242 (1628) | 5481 (1304) |
| Cholesterol (mmol/1) | 6.649 (0.346) | 5.663 (0.291) | 5.906 (0.565) |
| Triglycerides (mmol/l) | 0.518 (0.049) | 0.436 (0.040) | 0.465 (0.068) |
| Free fatty acids (meq/l) | 2.164 (0.075) | 2.036 (0.121) | 1.646 (0.078)** |