Demographic differences between the fast and slow fibrosis groups
| Fast (cirrhosis in less than 30 y) | Slow (more than 30 y to cirrhosis) | Comparisons | Total (for ANOVA) | |
|---|---|---|---|---|
| IVDU, intravenous drug use. | ||||
| Male | 111 | 87 | p=0.001 | 198 |
| Female | 59 | 95 | 154 | |
| Age at infection (y) | 32.38 | 22.0 | p<0.001 | 27.06 |
| Risk factor | ||||
| Blood | 79 | 94 | 173 | |
| IVDU | 91 | 88 | NS | 179 |
| Alcohol | ||||
| Nil | 91 (53) | 101 (55.2) | 192 (54.4) | |
| Minimal (<20units/week) | 27 (16) | 27 (14.8) | 54 (15.3) | |
| Moderate (20–40 units/week) | 6 (3) | 6 (3.3) | 12 (3.4) | |
| Heavy (40+ units/week) | 17 (1) | 17 (9.3) | NS | 34 (9.5) |
| Unknown | 29 (17) | 32 (17.5) | 60 (17.2) | |
| Viral genotype | ||||
| 1 | 62 (36.5) | 73 (39.9) | 135 (38.2) | |
| Non-1 | 44 (25.9) | 37 (20.2) | NS | 81 (22.9) |
| Unknown | 64 (37.6) | 72 (39.9) | 136 (38.9) | |
| Time infection to 1st biopsy (y) | 9.29 | 19.8 | p<0.001 | 14.7 |
| Fibrosis score (units) | ||||
| Mean | 3.72 | 1.68 | p<0.001 | 2.66 |
| 0 | 0 (0%) | 26 (14.3%) | 26 (7.4%) | |
| 1 | 12 (7%) | 58 (31.9%) | 70 (19.8%) | |
| 2 | 37 (21.8%) | 64 (35.2%) | 101 (28.9%) | |
| 3 | 31 (18.2%) | 22 (12.1%) | 53 (15%) | |
| 4 | 33 (19.4%) | 8 (4.4%) | 41 (11.6%) | |
| 5 | 21 (12.3%) | 2 (1.1%) | 23 (6.5%) | |
| 6 | 36 (21.2) | 2 (1.1%) | 38 (10.8%) | |
| Total | 170 | 182 | 352 | |
| Necroinflammatory score (units) | 5.15 | 3.7 | p<0.001 | 4.4 |
| Median rate of fibrosis (fibrosis units/y) | 0.4 | 0.08 | p<0.001 | 0.2 |