Ion channel | Activating temperature | Activators |
---|---|---|
VRL-1 (TRPV2) | ∼53° C | Noxious heat |
VR1 (TRPV1) | ∼43° C (lower temperatures on sensitisation) | Noxious heat, capsaicin, pH <5.9 |
TRPV3/TRPV4 (VRL-2) | 30–40° C | Warm |
CMR1/TRPM8 | ∼25° C | Cold menthol |
ANKTM1 | <17° C | Noxious cold |