Vital parameters and liver function tests in rats after 3 weeks of treatment
| Parameters | Control | SSR182289 | CCl4 | CCl4+SSR182289 |
|---|---|---|---|---|
| *p⩽0.05 compared with CCl4 group. Values are mean (standard deviation). | ||||
| Body weight (g) | 374.4 (29.1) | 354.9 (15.7) | 325.8 (24.3) | 317.2 (12.8) |
| Liver weight (g) | 14.4 (2.4) | 13.5 (0.9) | 15.3 (2.5) | 13.2 (1.3)* |
| LW:BW ratio (×100) | 3.8 (0.4) | 3.8 (0.1) | 4.7 (0.6) | 4.2 (0.3)* |
| ASAT (IU/l) | 89.9 (17.5) | 113.2 (29.0) | 269.3 (133.9) | 205.0 (98.2) |
| ALAT (IU/l) | 48.6 (8.2) | 46.2 (6.6) | 285.7 (173.0) | 202.6 (129.2) |
| AP (IU/l) | 168.1 (47.6) | 188.1 (63.8) | 300.0 (50.2) | 247.8 (68.9) |
| Bilirubin (µM/l) | 2.6 (1.0) | 2.3 (0.7) | 2.4 (1.6) | 2.7 (0.7) |