Heart rate and mean arterial pressure in the three groups of rats with cirrhosis
| Heart rate (beats/min) | Mean arterial pressure (mm Hg) | |||||
|---|---|---|---|---|---|---|
| Control (n = 3) | LPS (n = 4) | LPS + tezosentan (n = 6) | Control (n = 3) | LPS (n = 4) | LPS + tezosentan (n = 6) | |
| Measurements were performed every 15 minutes (results are presented as mean for one hour). | ||||||
| Cirrhotic rats received either lipopolysaccharide (LPS) or placebo at one hour and tezosentan or placebo at two hours. | ||||||
| Control group, rats received placebo and placebo; LPS group, rats received LPS and placebo; LPS + tezosentan group, rats received LPS and tezosentan. | ||||||
| Values are mean (SEM). | ||||||
| *Significantly different from the control group; †significantly different from the LPS group. | ||||||
| 0–1 h | 352 (13) | 388 (21) | 368 (8) | 97 (2) | 95 (3) | 103 (3) |
| 1–2 h | 351 (11) | 400 (24)* | 425 (6)* | 102 (5) | 78 (4)* | 92 (4)† |
| 2–3 h | 372 (22) | 397 (18) | 411 (16) | 104 (5) | 86 (1)* | 87 (3)* |
| 3–4 h | 347 (4) | 389 (30) | 415 (10)* | 99 (5) | 94 (7) | 92 (5) |
| 4–5 h | 345 (10) | 389 (31) | 425 (10)* | 103 (2) | 93 (10) | 91 (8) |