Prevalence of a determinant mutants in serum samples from children less than 15 years of age enrolled in the seroepidemiological surveys in 1984, 1989, 1994, and 1999
| 1984 survey | 1989 survey | 1994 survey | 1999 survey | |
|---|---|---|---|---|
| †The methods used for selection of children for hepatitis B virus (HBV)-DNA testing from surveyed children and various a determinant variants detected in 1984, 1989, and 1994 have been described by Hsu and colleagues8 and those in 1999 are described in the text. | ||||
| ‡Data in parentheses are percentage of children with a determinant mutants in HBV-DNA positive children in the survey. | ||||
| *p = 0.059, **p = 0.0064, ***p = 0.203, ****p = 0.91, *****p = 0.98 by χ2 test with Yates’ correction. | ||||
| No of children surveyed for HBV markers† | 1200 | 1134 | 1515 | 1357 |
| No of children analysed for serum HBV-DNA | 148 | 91 | 65 | 71 |
| No of children seropositive for HBV-DNA | 103* ** *** | 51* **** | 32** ***** | 13*** **** ***** |
| No of children who harboured a determinant mutant‡ | 8 (7.8%)* ** *** | 10 (19.6%)* **** | 9 (28.1%)** ***** | 3 (23.1%) *** **** ***** |
| Various a determinant detected (No) | T126A (1), M133L(1) F134L(1), C138S(1) T140R(1), T140I(1) T143M(1), D144A(1) | T126A(2),P127T(1) Q129H(1), S143W(mix)(2), G145R(mix)(1) G145R(2), W156L(1) | T125A(1), P120Q+P127T(1) T126A+T143M (1) T126S(mix)+D144H (mix)(1) D144H(mix)+G145R(1) T140P(mix)(1) N146S(1), T148I(1) C147R(mix)+C149R(mix)(1) | T131I(1) G145R(2) |