Effect of R-1 and R-2 mAb on several markers in animals treated with CCl4
| Group | Hyaluronic acid (ng/ml) | P-III-P (ng/ml) | ALT (U/ml) | Total bilirubin (mg/dl) |
|---|---|---|---|---|
| Data are means (SD) (n=8). | ||||
| P-III-P, procollagen III-N-peptide; ALT, aminotransferase aspartate; R1 mAb, VEGFR-1 monoclonal antibody; R2 mAb, VEGFR-2 monoclonal antibody; R1+R2, R1 mAb+R2 mAb. | ||||
| **p<0.01 compared with the control group; ††p<0.01 compared with the R1 mAb treated group. | ||||
| Contro l | 190.2 (27.5) | 46.3 (6.4) | 242.4 (51.8) | 1.4 (0.2) |
| R1 mAb | 82.7 (17.4)** | 20.6 (6.0)** | 216.4 (55.7) | 1.1 (0.2) |
| R2 mAb | 28.7 (14.3)†† | 7.1 (3.4)†† | 233.8 (60.8) | 1.2 (0.2) |
| R1+R2 | 18.6 (7.9) | 3.8 (1.9) | 226.3 (54.5) | 1.1 (0.3) |
| Oil | 11.4 (3.0) | 2.4 (1.1) | 45.1 (7.3) | 0.6 (0.2 |