Affinities of serotonin (5-hydroxytryptamine or 5-HT) and some antidepressants for monoamine transporters
| Compound | SERT | NET | DAT |
|---|---|---|---|
| Values are expressed as KD values (geometric mean (SEM) in nM) and are taken from Tatsumi and colleagues.178 | |||
| SERT, 5-HT transporter; DAT, dopamine transporter; NET, noradrenaline transporter. | |||
| Amitriptyline | 4.30 (0.12) | 35 (2) | 3250 (20) |
| Citalopram | 1.16 (0.01) | 4070 (80) | 28 100 (700) |
| Desipramine | 17.6 (0.7) | 0.83 (0.05) | 3190 (40) |
| Fluoxetine | 0.81 (0.02) | 240 (10) | 3600 (100) |
| Imipramine | 1.40 (0.03) | 37 (2) | 8500 (100) |
| Paroxetine | 0.13 (0.01) | 40 (2) | 490 (20) |
| 5-HT | 2100 (100) | >100 000 | >100 000 |