Table 1

Comparison of phenotypes between the genotype “APC mutation not identified” and the genotypes “mutation identified in the CRC-MCR domain” and “mutation identified in the post-CRC-MCR domain

PhenotypeGenotype
APC mutation identified?Mutation in CRC-MCR domain?Mutation in post-CRC-MCR domain?
YesNop ValueYesNop ValueYesNop Value
FAP, familial adenomatous polyposis; APC, adenomatous polyposis coli gene; CRC-MCR, colorectal cancer mutation cluster region.
*Call up patients only.
†Probands only.
‡The mean value for the trait was highest in patients without an identified mutation in APC or in those with a mutation identified either in the CRC-MCR domain or in the post-CRC-MCR domain.
§The mean value for the trait was lowest in patients without an identified mutation in APC or in those with a mutation identified either in the CRC-MCR domain or in the post-CRC-MCR domain.
Single symbols (‡ or §) indicate when the tendency was the same as for patients without an identified mutation, and double symbols (‡‡ or §§) when different.
Mean No of affected persons in the familiesn4822939444
Mean4.62.3§0.023.6§4.8NS5.5‡‡4.5NS
Age at colon adenoma development (y)*n334330330
Mean21.331.6‡0.098.4§§22.70.0232.6‡20.2NS
Age at symptoms (y)†n71281655467
Mean36.331.2§0.0828.1§38.70.0043.2‡‡35.9NS
Age at diagnosis of CRC (y)n56191046155
Mean42.740.1§NS34.2§44.50.0151.2‡‡42.4NS
Age at diagnosis of FAP (y)†n8821969583
Mean37.833.8§NS30.4§39.80.0042.7‡‡37.5NS
Spigelman stagen66168581056
Mean1.350.50§0.011.50‡‡1.33NS1.20§1.38NS
Age at death (y)n67201255364
Mean47.439.6§0.0142.9§50.4NS59.3‡‡48.2NS