Table 2

Odds ratio for finding the listed traits in affected persons with regard to mutational status

PhenotypeGenotype
APC mutation identified? No v yesMutation in CRC-MCR domain? Yes v noMutation in post CRC-MCR domain? Yes v no
n*Odds ratiop Valuen*Odds ratiop Valuen*Odds ratiop Value
APC, adenomatous polyposis coli gene; CRC-MCR, colorectal cancer mutation cluster region.
*Number differs between traits due to difference in unknown cases.
**Osteomas only found in patients with identified mutations (n = 7).
***All patients with an identified mutation in this region (n = 4) had mandibular osteomas.
****No patient with an identified mutation in this region (n = 27) had desmoid tumours.
‡Odds for finding the trait in a patient without an identified mutation in APC and in those with a mutation in the CRC-MCR domain or in the post-CRC-MCR is highest.
§Odds for finding the trait in a patient without an identified mutation in APC and in those with a mutation in the CRC-MCR domain or in the post CRC-MCR is lowest.
Single symbols (‡ or §) indicate when the tendency was the same as for patients without an identified mutation, and double symbols (‡‡ or §§) when different.
Family with isolated case701.86‡NS484.84‡0.03483.00‡NS
Epidermoid cysts2700.72§NS2182.69‡‡0.072182.05‡‡NS
Osteomas270**§NS2180.99NS2187.58‡‡0.00
Mandibular osteomas650.32§0.08531.83‡‡NS53***‡‡NS
Desmoids2331.08‡NS184****§§NS1844.46‡0.01
Colorectal cancer2681.50‡NS2161.44‡NS2160.11§§0.01
>1000 colorectal adenomas1920.27§0.001563.28‡‡0.011560.34§NS
Fundic gland polyposis840.30§0.05660.60§NS6612.99‡‡0.00
Duodenal adenomas820.24§0.01661.14‡‡NS661.30‡‡NS