Perceptual thresholds (mean (SEM)) in diarrhoea predominant irritable bowel syndrome (d-IBS) patients and control subjects during acute tryptophan depletion (ATD) and placebo
| d-IBS patients | Controls | ATD v placebo (p value) | ||
|---|---|---|---|---|
| Pressure threshold (mm Hg) | ||||
| First perception | ATD | 10.6 (1.2) | 12.6 (1.3) | 0.003* |
| Placebo | 13.6 (0.8) | 15.7 (1.2) | ||
| Maximal tolerable discomfort | ATD | 50.5 (3.6) | 50.9 (3.3) | 0.8 |
| Placebo | 51.6 (3.3) | 48.8 (2.9) |