Polymorphisms tested
| Polymorphism | dbSNP | Allele/phenotype frequencies | Method |
|---|---|---|---|
| See http://www.ncbi.nlm.nih.gov/SNP/ for dbSNP details. | |||
| MTHFR, methylene tetrahydrofolate reductase; NAT, N-acetyltransferase; GST, glutathione S-transferase; CCND1, cyclin D1; CDH1, cellular dose of E-cadherin; SNP, single nucleotide polymorphism. | |||
| MTHFR C677T | rs1801133 | C: 0.76; T: 0.24 | Frosst36 |
| MTHFR A1298C | rs1801131 | A: 0.78; C: 0.22 | van der Put26 |
| NAT1*10 | rs1057126 | Homo-/heterozygote: 0.43; all other genotypes: 0.57 | Bell15 |
| rs15561 | |||
| NAT2 | rs1799929 | Fast acetylator allele hom/het: 0.56; slow acetylator alleles: 0.44 | Smith18 |
| rs1799930 | |||
| rs1208 | |||
| rs1799931 | |||
| GSTT1*null | n/a | Null homozygote: 0.31; all other genotypes: 0.69 | Pemble37 |
| GSTM1*null | n/a | Null homozygote: 0.53; all other genotypes: 0.47 | Fryer38 |
| CCDN1 870G/A | rs603965 | G: 0.58; A: 0.42 | Porter28 |
| CDH1–160C/A | rs16260 | C: 0.78; A: 0.22 | Porter28 |
| APC promoter | rs2019720 | G: 0.51; A: 0.49 | This study |
| APC V1822D | rs459552 | T: 0.82; A: 0.18 | This study |
| APC G1678A | rs42427 | G: 0.11; A: 0.89 | This study |
| APC T1493C | rs41115 | T: 0.85; C: 0.15 | This study |