Differential effect of CD2 and CD3 activation on lamina propria T cell (LPT) cell cycle kinetics
| G0/G1 traverse time* | S traverse time* | G2/M traverse time* | Potential doubling time (Tpot)* | Cells in mitosis (%)† | |
|---|---|---|---|---|---|
| CD, Crohn’s disease; UC, ulcerative colitis. | |||||
| *Values represent time in hours. | |||||
| †Percentage of phospho-histone H3 positive cells at 72 hours. | |||||
| Control anti-CD2 | 8.5 (0.9) | 25.8 (3.0) | 7.6 (1.1) | 41.9 | 0.69 (0.07) |
| Control anti-CD3 | 8.1 (1.1) | 30.5 (3.2) | 6.3 (0.6) | 44.9 | 0.53 (0.09) |
| CD anti-CD2 | 6.7 (0.9) | 13.8 (1.9) | 5.7 (0.9) | 26.2 | 1.31 (0.16) |
| CD anti-CD3 | 7.1 (1.1) | 14.9 (1.3) | 5.4 (0.7) | 27.4 | 1.26 (0.14) |
| UC anti-CD2 | 7.9 (0.8) | 31.3 (2.4) | 6.9 (1.0) | 46.1 | 0.49 (0.04) |
| UC anti-CD3 | 8.8 (0.9) | 35.4 (3.5) | 6.8 (0.8) | 51.0 | 0.44 (0.05) |