Blockade of Fas signal transduction in vivo reduces hepatocyte apoptosis in interleukin 18 transgenic (IL-18 Tg) mice
| Hepatocytes IL-18 Tg | +β-Gal | +Adv-dnFADD | +Adv-IkBα |
|---|---|---|---|
| IL-18 Tg mice were infected with 1010 PFU of adenoviruses (Adv) expressing dominant negative Fas associated death domain (dnFADD), IκB, or β-galactosidase (β-Gal) intraperitoneally for three days followed by analysis of hepatocyte apoptosis by annexin V/propidium iodide (PI) staining by FACS. | |||
| Results are reported as per cent of apoptotic cells. | |||
| Annexinhigh/PIhigh | 67.33 (5.3) | 29.90 (3.18) | 65.27 (27.45) |