Multivariate analysis on maturation of fibrotic cancer stroma and other prognostic factors. Maturation of fibrotic cancer stroma was significant by multivariate analysis
| Variables selected* | Coefficient | SE | χ2 | HR (95% CI) | p Value |
|---|---|---|---|---|---|
| *Only variables found to be significant in the model using a stepwise Cox regression model were included. The variables analysed and their categories and scores were: (1) age (<60 = 0, ⩾60 = 1); (2) maximum diameter of tumour (<5 cm = 0, ⩾5 cm = 1); (3) tumour phenotype (well = 0, moderate = 1, poor/mucinous = 2); (4) nodal involvement (pN0 = 0, pN1 = 1, pN2 = 2); (5) extramural venous invasion (absent = 0, present = 1); (6) intensity of tumour budding (score I/II = 0, score III/IV = 1); (7) maturation of fibrotic cancer stroma (mature = 0, intermediate = 1, immature = 2). | |||||
| HR, hazard ratio; CI, confidence interval. | |||||
| Nodal involvement | 0.51 | 0.08 | 43.01 | 1.67 (1.43–1.94) | <0.0001 |
| Intensity of tumour budding | 0.62 | 0.13 | 21.64 | 1.85 (1.43–2.40) | <0.0001 |
| Maturation of fibrotic cancer stroma | 0.35 | 0.09 | 16.38 | 1.41 (1.20–1.67) | <0.0001 |
| Tumour phenotype | 0.34 | 0.10 | 11.46 | 1.41 (1.15–1.71) | 0.0007 |
| Extramural venous invasion | 0.32 | 0.11 | 7.83 | 1.38 (1.10–1.72) | 0.0051 |