Mean somatic scores (SoSc) and percentage of abnormal SoSc for each genotype combination in patients with lower functional gastrointestinal disorders and healthy controls
| N | SLC6A4 | α2C Del 322–325 | α2A −1291 (C→G) | SoSC score (mean) (SD) | % High score | OR (95% CI)* |
|---|---|---|---|---|---|---|
| The high somatic symptom score refers to >0.75, the 90th percentile for healthy controls. | ||||||
| *Estimated odds ratio (95% confidence interval) from logistic regression model adjusting for race and sex. | ||||||
| Wt, wild-type; Het, Heterozygous; hom, homozygous polymorphism. | ||||||
| 51 | Wt | Wt | Wt | 0.67 (0.57) | 33% | 1.0 (ref) |
| 51 | Wt | Wt | Het/hom | 0.74 (0.49) | 41% | 1.4 (0.6,3.1) |
| 9 | Wt | Het/hom | Wt | 0.77 (0.65) | 44% | 1.7 (0.4,7.3) |
| 6 | Wt | Het/hom | Het/hom | 0.94 (0.24) | 83% | 11.1 (1.1, 100.1) |
| 108 | Het/hom | Wt | Wt | 0.59 (0.57) | 30% | 0.8 (0.4, 1.7) |
| 90 | Het/hom | Wt | Het/hom | 0.76 (0.58) | 40% | 1.3 (0.6, 7.8) |
| 10 | Het/hom | Het/hom | Wt | 1.23 (0.79) | 70% | 5.0 (1.1, 22.2) |
| 9 | Het/hom | Het/hom | Het/hom | 0.53 (0.43) | 22% | 0.6 (0.1, 3.4) |