Table 1

Genotype distributions of gene polymorphisms missing the Hardy-Weinberg equilibrium (HWE) in studies published in Gut between 1998 (volume 42) and 2003 (volume 52)

Publication [reference]	Gene polymorphism	Subjects	Genotype distribution WW/WM/MM	HWE p value
WW, number of patients with homozygosity for wild allele; WM, number of patients with heterozygosity, MM, number of patients with homozygosity for mutant allele.
1998;43:187–9.⁷	CTLA-4 exon 1 position 49	Controls	62/47/21	0.034
1998;43:187–9.⁷	CTLA-4 exon 1 position 49	HLA DR3 negative controls	54/36/16	0.027
2001;48:836–42.⁹	HFE H63D polymorphism haplotypes	Iron overload patients	178/85/60	0.001
2002;50:520–4.¹¹	Methylene tetrahydrofolate reductase	Controls	533/560/114	0.053
		Control, 60 y<	204/229/34	0.005
		Female colorectal cancer patients	134/101/35	0.031
		Colorectal cancer stage: Dukes’ B	94/64/28	0.003
		Colorectal cancer and p53 mutation−	148/116/39	0.036
2003;52:547–51.⁸	CYPA1A1 exon7	Controls	122/22/5	0.012
2003;52:547–51.⁸	EPXH exon 3	Controls	59/58/32	0.018
2003;52:558–62.¹⁰	NOD2 gene 1007fs variant	Crohn’s disease patients	248/20/3	0.017