Statistical power to detect genotype differences with this study sample
| No with genotype SLC6A4 (Wt) | % with phenotype | No with genotype SLC6A4 (het/hom) | ⩾80% power† to detect this proportion (%) with phenotype |
|---|---|---|---|
| 137 | Any FGID: 73% | 259 | Any FGID: ⩾85% (or⩽61%) |
| 73 | IBS-C: 49% | 137 | IBS-C: ⩾69% (or ⩽29%) |
| 78 | IBS-D: 53% | 170 | IBS-D: ⩾72% (or ⩽32%) |
| No with genotype α2C Del 322–325 (Wt) | % with phenotype | No with genotype α2C Del 322–325 (het/hom) | ⩾80% power† to detect this proportion (%) with phenotype |
|---|---|---|---|
| 348 | Any FGID: 68% | 39 | Any FGID: ⩾88% (or ⩽48%) |
| 183 | IBS-C: 40% | 22 | IBS-C: ⩾71% (or ⩽9%) |
| 224 | IBS-D: 51% | 20 | IBS-D: ⩾82% (or ⩽20%) |
| No with genotype α2A −1291 (C→G) (Wt) | % with phenotype | No with genotype α2A −1291 (C→G) (het/hom) | ⩾80% power† to detect this proportion (%) with phenotype |
|---|---|---|---|
| 210 | Any FGID: 67% | 182 | Any FGID: ⩾80% (or ⩽54%) |
| 109 | IBS-C: 37% | 99 | IBS-C: ⩾57% (or ⩽17%) |
| 140 | IBS-D: 51% | 108 | IBS-D: ⩾69% (or ⩽33%) |
| No with genotype α2A −1291 (C→G) (Wt) and SLC6A4 (Wt) | % with phenotype | No with genotype α2A −1291 (C→G) (het/hom) and SLC6A4 (het/hom) | ⩾80% power† to detect this proportion (%) with phenotype |
|---|---|---|---|
| †Based on two sample test for proportions using a two sided alpha level of 0.05. | |||
| IBS-C, irritable bowel syndrome with predominant constipation; IBS-D, irritable bowel syndrome with predominant diarrhoea; FGID, functional gastrointestinal disorders. | |||
| 68 | Any FGID: 71% | 115 | Any FGID: >88% (or <52%) |
| 39 | IBS-C: 49% | 66 | IBS-C: >76% (or <22%) |
| 39 | IBS-D: 49% | 69 | IBS-D: >76% (or <22%) |