Demographic and clinical characteristics of the Crohn’s disease study population
| Characteristic | Cohort 1 (n = 334) | Cohort 2 (n = 114) | p Value* |
|---|---|---|---|
| *p values are adjusted for familial correlation. | |||
| ASCA, anti-Saccharomyces cerevisiae antibody. | |||
| Age at diagnosis (y) (mean (SD)) | 26.6 (10.3) | 28.9 (12.4) | 0.044 |
| Sex (% female) | 198 (59.3%) | 50 (43.8%) | 0.003 |
| Localisation | |||
| Ileitis | 110 (32.9%) | 33 (28.9%) | NS |
| Ileocolitis | 179 (53.6%) | 63 (55.3%) | NS |
| Colitis | 45 (13.5%) | 18 (15.8%) | NS |
| Anal involvement | 133 (39.8%) | 36 (31.6%) | NS |
| Upper involvement | 29 (8.7%) | 8 (7.0%) | NS |
| Behaviour | |||
| Non-stricturing, non-penetrating | 77 (23.1%) | 18 (15.8%) | NS |
| Stricturing | 173 (51.8%) | 56 (49.1%) | NS |
| Penetrating | 84 (25.1%) | 40 (35.1%) | 0.042 |
| Familial disease | 192 (57.5%) | 13 (11.4%) | <0.001 |
| Surgery | 198 (59.3%) | 64 (56.1%) | NS |
| Smoking | 153 (45.8%) | 43 (37.7%) | NS |
| Extraintestinal manifestations | 117 (35.0%) | 39 (34.2%) | NS |
| ASCA | 176 (52.7%) | 53 (46.5%) | NS |