Frequencies of the interleukin 10 (IL-10) haplotype combinations in patients with different degrees of granulocytic (G) and lymphocytic (L) infiltration, as well as the presence or absence of intestinal metaplasia (IM) and atrophic gastritis (AG)
| Antrum | G2/G3 (n = 152) | G0/G1 (n = 55) | OR (95% CI) | L2/L3 (n = 162) | L1 (n = 45) | OR (95% CI) | IM (n = 64) | Non-IM (n = 143) | OR (95% CI) | AG (n = 49) | Non-AG (n = 158) | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GCC−ATA+ | 35 | 16 | 1.0 | 44 | 7 | 1.0 | 11 | 40 | 1.0 | 7 | 44 | 1.0 |
| 23% | 29% | Ref | 27% | 16% | Ref | 17% | 30% | Ref | 14% | 28% | Ref | |
| GCC+ATA− | 65 | 24 | 1.2 | 69 | 20 | 0.6 | 34 | 55 | 2.3 | 24 | 65 | 2.3 |
| 43% | 44% | (0.5–1.8) | 43% | 44% | (0.2–1.5) | 53% | 39% | (1.0–5.5) | 49% | 41% | (0.9–6.9) |
| G2/G3 | G0/G1 | OR | L2/L3 | L1 | OR | IM | Non-IM | OR | AG | Non-AG | OR | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Corpus | (n = 84) | (n = 123) | (95% CI) | (n = 62) | (n = 145) | (95% CI) | (n = 12) | (n = 195) | (95% CI) | (n = 12) | (n = 195) | (95% CI) |
| Ref, reference. | ||||||||||||
| G0, absent; G1, mild; G2, moderate; G3, severe granulocytic infiltration. | ||||||||||||
| L1, mild; L2, moderate; L3, severe lymphocytic infiltration. | ||||||||||||
| GCC−/ATA+, low IL-10 secreting haplotype combination; GCC+/ATA−, high IL-10 secreting haplotype combination. | ||||||||||||
| Odds ratios (OR) with exact 95% confidence intervals (CI) were calculated using StatXact-4.0.1 software. | ||||||||||||
| GCC−ATA+ | 15 | 36 | 1.0 | 13 | 38 | 1.0 | 3 | 48 | 1.0 | 1 | 50 | 1.0 |
| 18% | 29% | Ref | 21% | 26% | Ref | 25% | 25% | Ref | 8% | 26% | Ref | |
| GCC+ATA− | 38 | 51 | 1.8 | 32 | 57 | 1.6 | 6 | 83 | 1.2 | 7 | 82 | 4.2 |
| 45% | 42% | (0.8–4.0) | 52% | 39% | (0.7–3.9) | 50% | 43% | (0.2–7.5) | 58% | 42% | (0.5–196.1) | |