Study (reference)‡ | Radiotherapy | Chemotherapy | Surgery | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Total dose (Gy) | Fractions (No/days) | Daily dose (Gy) | BED >(Gy) | BED corrected by time (Gy) | Drugs | Dosage >(mg/m2) | Schedules >(day) | Interval between end of irradiation and surgery (weeks) | ||
*Tpot squamo = 4.5 days33; †Tpotadeno = 6 days,33 α = 0.3 | ||||||||||
BED, biological equivalent dose; CDDP, cisplatin; BLM, bleomycin; 5-FU, 5-fluorouracil; VNB, vinblastin. | ||||||||||
‡For expansion of the study names, see corresponding reference. | ||||||||||
1 | Nygaard et al12 | 35 | 20/28 | 1.75 | 41.12 | 26.7* | CDDP | 20 | 1–5; 15–19 | 3 |
BLM | 5 | |||||||||
2 | Le Prise et al13 | 20 | 10/12 | 2 | 24 | 17.8* | CDDP | |||
5FU | 100 | 1; 21 | 2.5 | |||||||
600 | 2–5; 22–25 | |||||||||
3 | Apinop et al14 | 40 | 20/28 | 2 | 48 | 33.6* | CDDP | 100 | 1; 29 | 4 |
5FU | 1000 | 1–4;29–32 | ||||||||
4 | Walsh et al15 | 40 | 15/21 | 2.67 | 50.7 | 42.6† | CDDP | 75 | 7;42 | 2 |
5FU | 15 mg/kg | 1–5;36–40 | ||||||||
5 | Bosset et al16 | 37 | 10/24 | 3.7 | 50.7 | 38.4* | CDDP | 80 | 0–2;19–21 | 2–4 |
6 | Urba et al17 | 45 | 30/21 | 1.5×2 | 51.7 | 43.6† >adenoca. | CDDP | 20 | 1–5;17–21 | 3 |
40.9* >squamo. | 5FU | 300 | 1–21 | |||||||
VNB | 1 | 1–4;17–20 |