Group | Lesion index* (mm) | MPO activity* (U/mg) |
---|---|---|
*Data are mean (SEM) of 4–6 mice per group. | ||
iNOS, inducible nitric oxide synthase; MPO, myeloperoxidase. | ||
††p<0.01, indomethacin+saline (iNOS−/−) versus indomethacin (wild-type mice). | ||
‡‡‡p<0.001, indomethacin+l-NAME (iNOS−/−) versus indomethacin (wild-type mice). | ||
Vehicle (Tris buffer) | 0.0 (0.0) | 0.64 (0.06) |
Indomethacin (wild-type mice) | 23.1 (3.7) | 5.36 (0.26) |
Indomethacin+saline (iNOS−/−) | 12.5 (2.6)†† | 6.46 (1.02) |
Indomethacin+l-NAME (iNOS−/−) | 9.3 (0.7)‡‡‡ | 8.52 (0.74)‡‡‡ |