Number of mast cells and scores for expression of NSE, SP, 5-HT, and CGRP positive nerve fibres in the intestinal mucosa of post-infective irritable bowel syndrome (PI-IBS) and non-PI-IBS patients and controls
| PI-IBS patients (n = 27) | Non-PI-IBS (n = 29) | Controls (n = 12) | p Value | |
|---|---|---|---|---|
| *p<0.05 compared with control subjects. | ||||
| NSE, neurone specific enolase; SP, substance P; CGRP, calcitonin gene related peptide; 5-HT, 5-hydroxytryptamine. | ||||
| Terminal ileum | ||||
| Mast cell | 11.19 (2.83)* | 10.78 (1.23)* | 6.05 (0.51) | <0.01 |
| NSE | 3.59 (0.50)* | 3.34 (0.61)* | 2.73 (0.90) | <0.05 |
| SP | 2.78 (0.89)* | 2.69 (0.85)* | 1.91 (0.70) | <0.05 |
| 5-HT | 2.85 (0.82)* | 2.76 (0.91)* | 2.09 (0.83) | <0.05 |
| CGRP | 2.26 (1.20) | 2.14 (0.69) | 2.09 (1.04) | >0.05 |
| Rectosigmoid | ||||
| Mast cell | 6.14 (0.43) | 5.96 (0.43) | 5.79 (0.48) | >0.05 |
| NSE | 3.37 (0.56)* | 3.28 (0.80)* | 2.55 (1.21) | <0.05 |
| SP | 2.89 (0.80)* | 2.62 (1.73)* | 2.00 (0.77) | <0.05 |
| 5-HT | 2.74 (0.71)* | 2.72 (0.96)* | 2.01 (1.13) | <0.05 |
| CGRP | 2.44 (1.05) | 2.38 (1.01)* | 2.27 (1.35) | >0.05 |