Table 4

 Annotated genes differentially expressed in Marsh III (MIII) biopsies with or without gluten, grouped according to functional pathways*

Gene symbolGene nameLocusLink IDChromosome locationRatio gluten−/gluten+†
*All of the genes can be found at http://humgen.med.uu.nl/publications/CD/Microarrays/Diosdado_1.html.
†Ratio of the expression level for each individual gene between biopsies from MIII coeliac disease patients on a gluten free diet (gluten−) and MIII coeliac disease patients following a gluten containing diet (gluten+). Genes with values <1 are downregulated; genes with values >1 are upregulated.
‡Genes located in more than one functional group.
HLA and immune function genes
    C5R1Complement component 5 receptor 172819q13.321.14
    CD79BCD79B antigen97417q23.31.14
    MAP4K4Mitogen activated protein kinase kinase kinase kinase 494482q11.21.31
    ITGA4Integrin, alpha 436762q31.31.39
Chemokines, cytokines, and growth factors
    None
Inflammatory mediators
    PDE4DPhosphodiesterase 4D, cAMP specific51445q11.20.67
    AUH‡AU specific RNA binding protein5499q22.310.86
Cancer related genes
    DEPC-1Prostate cancer antigen-122112011p120.79
    M17S2Membrane component, chromosome 17, surface marker 2407717q21.311.24
    RABL2BRAB-like protein 2B1115822q13.331.35
Structure related genes
    ADAMTS9A disintegrin-like and metalloprotease with thrombospondin type 1 motif, 9569993p14.10.74
    ADRM1Adhesion regulating molecule 11104720q13.330.82
    KLKlotho936513q13.11.11
    FN1Fibronectin 123352q351.30
Metabolic pathways and ion transport mediators
    PREPProlyl endopeptidase55506q210.56
    PLCB4Phospholipase C, beta 4533220p12.20.79
    AUH‡AU specific RNA binding protein5499q22.310.86
    RYR3Ryanodine receptor 3626315q141.22
    IDH3AIsocitrate dehydrogenase 3, alpha subunit341915q25.11.21
    BG1Lipidosin2320515q231.21
    SLC25A4Adenine nucleotide translocator 12914q35.11.25
    CPT1ACarnitine palmitoyltransferase I, liver137411q13.31.31
Cell cycle regulators and transcription factors
    LOC51174Delta-tubulin5117417q23.20.54
    KIF5BKinesin family member 5B379910p11.220.76
    CCNG1cyclin G19005q340.77
    NT5C25′-nucleotidase, cytosolic II2297810q24.320.83
    ZNF26Zinc finger protein 26757412q24.331.19
    POLR2CPolymerase II, RNA subunit C543216q131.19
    GTF2H1General transcription factor IIH, polypeptide 1296511p15.11.24
    MSI2Musashi homologue 2 (Drosophila)12454017q23.21.28
    ZNF317Zinc finger protein 3175769319p13.21.32
    CDC25ACell division cycle 25A9933p21.311.46
    PPP2R3AProtein phosphatase 2 (formerly 2A), regulatory subunit B’, alpha55233q22.31.49
    POLD3DNA polymerase delta subunit 31071411q13.41.58
Signal transduction
    SYPLSynaptophysin-like protein68567q22.30.79
    WACWW domain containing adapter with a coiled-coil region5132210p12.10.83
    HNTNeurotrimin508630.86
    RGS16Regulator of G protein signalling 1660041q25.31.23
    PSCD3Pleckstrin homology, Sec7, and coiled/coil domains 392657p22.11.33
    CSPG6Chondroitin sulphate proteoglycan 6 (bamacan)912610q25.21.36
Others
Pro-neuregulin-3 precursor10q23.10.69
    HSPA6Heat shock 70 kDa protein 633101q23.30.76
    SARMSterile alpha and HEAT/Armadillo motif protein, orthologue of Drosophila2309817q11.21.26
    AMSHAssociated molecule with the SH3 domain of STAM106172p13.11.29
    PERQ1Postmeiotic segregation increased 2-like 12645997q22.11.59
    HTF9CHpaII tiny fragments locus 9C2703722q11.211.61