Sensory thresholds to electrical stimulation (ES) of the rectum
| First stage (saline) | Second stage (αhCRH 9–41) | p Value | |
|---|---|---|---|
| Data are expressed as mean (SEM) (mA). There was no significant change between the two stages of the experiment by the paired t test. However, all thresholds in the antagonist stage (second stage) showed higher mean values than those in the saline stage (first stage). | |||
| IBS, irritable bowel syndrome; αhCRH, α-helical corticotropin releasing hormone. | |||
| Control | |||
| First sensation (E) | 18.3 (3.2) | 19.5 (3.5) | 0.66 |
| Discomfort (E) | 24.4 (3.9) | 29.6 (3.8) | 0.059 |
| Pain (E) | 30.4 (3.9) | 36.3 (4.1) | 0.065 |
| IBS | |||
| First sensation (E) | 17.9 (2.8) | 20.7 (3.0) | 0.46 |
| Discomfort (E) | 23.7 (3.6) | 29.0 (3.6) | 0.13 |
| Pain (E) | 31.8 (3.8) | 37.8 (4.0) | 0.13 |