Interaction of DLG genotypes and OCTN haplotypes with risk associated CARD15 mutations in Crohn’s disease
| CARD15 mutant (risk associated) | CARD15 wild-type (non-risk associated) | p Value | ||
|---|---|---|---|---|
| DLG5 genotype | ||||
| 113G→A | GG | 193 (81.4%) | 308 (81.5%) | NS |
| AG | 40 (16.9%) | 67 (17.7%) | ||
| AA | 4 (1.7%) | 3 (0.8%) | ||
| 4136C→A | CC | 221 (93.2%) | 348 (92.1%) | NS |
| AC | 16 (6.8%) | 28 (7.4%) | ||
| AA | 0 (0.0%) | 2 (0.5%) | ||
| DLG5_e26 | insAinsA | 98 (41.3%) | 162 (42.8%) | NS |
| insAdelA | 109 (46.0%) | 176 (46.6%) | ||
| delAdelA | 30 (12.7%) | 40 (10.6%) | ||
| SLC22A4 | ||||
| 1672C→T | CC | 59 (24.7%) | 130 (33.7%) | 0.047 |
| CT | 114 (47.7%) | 169 (43.8%) | ||
| TT | 66 (27.6%) | 87 (22.5%) | ||
| SLC22A5 | ||||
| −207G→C | GG | 110 (27.2%) | 53 (22.2%) | NS |
| GC | 171 (44.3%) | 111 (46.4%) | ||
| CC | 105 (28.5%) | 75 (31.4%) | ||
| OCTN haplotype | ||||
| SLC22A4/SLC22A5 | ||||
| C/G | 215 (45.0%) | 391 (50.7%) | ||
| T/C | 244 (51.0%) | 343 (44.4%) | 0.0203 | |
| C/C | 17 (3.6%) | 38 (4.9%) | ||
| T/G | 2 (0.4%) | 0 (0.0%) |