Relative risk of developing colorectal cancer (CRC) among relatives of the 761 families according to tumour localisation
| CRC localisation of relative | Obs | Exp | SIR | 95% CI | p Value | ptrend |
|---|---|---|---|---|---|---|
| CRC localisation of proband | ||||||
| Obs, observed; Exp, expected; SIR, standardised incidence ratio; 95% CI, 95% confidence interval. | ||||||
| Colon-rectum-imprecise site | ||||||
| Caecum+ascending | 20 | 9.81 | 2.04 | 1.24–3.15 | 0.003 | |
| Transverse | 11 | 6.99 | 1.57 | 0.78–2.82 | NS | |
| Descending+sigmoid | 38 | 22.66 | 1.68 | 1.19–2.30 | 0.002 | 0.096 |
| RS junction+rectum | 36 | 28.46 | 1.26 | 0.89–1.75 | NS | |
| Unknown | 2 | 1.49 | – | – | – | |
| Total | 107 | 69.41 | 1.54 | 1.26–1.86 | <0.001 | |
| Colon | ||||||
| Caecum+ascending | 13 | 5.49 | 2.37 | 1.26–4.05 | 0.005 | |
| Transverse | 8 | 3.95 | 2.03 | 0.87–3.99 | NS | |
| Descending+sigmoid | 18 | 12.6 | 1.43 | 0.85–2.26 | NS | 0.03 |
| RS Junction+rectum | 18 | 15.88 | 1.13 | 0.67–1.79 | NS | |
| Unknown | 2 | 0.82 | – | – | – | |
| Total | 57 | 38.74 | 1.47 | 1.16–1.96 | 0.004 | |
| Rectum | ||||||
| Caecum+ascending | 7 | 4.46 | 1.57 | 0.63–3.23 | NS | |
| Transverse | 3 | 3.14 | 0.96 | 0.19–2.79 | NS | |
| Descending+sigmoid | 12 | 10.33 | 1.16 | 0.60–2.03 | NS | NS |
| RS Junction+rectum | 9 | 12.90 | 0.70 | 0.32–1.32 | NS | |
| Unknown | 0 | 0.68 | – | – | ||
| Total | 31 | 31.51 | 0.98 | 0.67–1.40 | NS | |