Five year cumulative rates (95% CI) of therapeutic intervention in the patients referred to our unit more than three months after diagnosis of Crohn’s disease (group 2, n = 2008)
| Cohort 1978–82 | Cohort 1983–87 | Cohort 1988–92 | Cohort 1993–97 | Cohort 1998–2002 | Log rank p value | |
|---|---|---|---|---|---|---|
| Patients (n) | 218 | 342 | 486 | 563 | 399 | |
| IS therapy | ||||||
| Cumulative probability (95% CI) | 0.04 (0.02–0.08) | 0.14 (0.10–0.18) | 0.27 (0.23–0.32) | 0.45 (0.40–0.50) | 0.63 (0.49–0.76) | <0.00001 |
| Patients at risk (n) | 195 | 278 | 296 | 203 | 17 | |
| Intestinal resection | ||||||
| Cumulative probability (95% CI) | 0.36 (0.29–0.48) | 0.30 (0.25–0.35) | 0.32 (0.28–0.37) | 0.31 (0.27–0.36) | 0.36 (0.22–0.53) | 0.528 |
| Patients at risk (n) | 137 | 227 | 274 | 263 | 21 | |
| Large intestinal resection | ||||||
| Cumulative probability (95% CI) | 0.29 (0.23–0.35) | 0.22 (0.18–0.27) | 0.19 (0.16–0.23) | 0.15 (0.11–0.19) | 0.12 (0.05–0.28) | <0.00001 |
| Patients at risk (n) | 145 | 250 | 321 | 310 | 27 | |
| Definitive stoma | ||||||
| Cumulative probability (95% CI) | 0.01 (0–0.03) | 0.02 (0.01–0.04) | 0.02 (0.01–0.04) | 0.02 (0.01–0.04) | 0.02 (0–0.13) | 0.72 |
| Patients at risk (n) | 202 | 315 | 387 | 355 | 33 |