Selected genes differentially expressed in LPL and IEL from VILLIN-HA×TCR-HA and TCR-HA mice
| Name | Regulation | Signal intensity | Cluster in fig 9 | |||
|---|---|---|---|---|---|---|
| LPL stg | LPL dtg | IEL stg | IEL dtg | |||
| Stg, T cell receptor (TCR)-HA; dtg, VILLIN-HA×TCR-HA; LPL, lamina propria lymphocytes; IEL, intraepithelial lymphocytes. | ||||||
| *Absent, defined by the Affymetrix software algorithm. | ||||||
| Genes in italics represent established markers of regulatory T cells. | ||||||
| Results are from pooled individual mice (n>3). | ||||||
| LPL and IEL proinflammatory | ||||||
| αΕβ7 | ↑ | 135 | 399 | 1206 | 2075 | A |
| S100a6 | ↑ | 158 | 1627 | 71 | 478 | A |
| Snx9 | ↑ | 159* | 357 | 82* | 483 | A |
| Tnfrsf7 | ↑ | 673 | 1377 | 436 | 1114 | A |
| CD83 | ↑ | 878 | 1225 | 237 | 992 | A |
| Tnfrsf9 | ↑ | 174 | 423 | 33* | 197 | A |
| LPL proinflammatory | ||||||
| Itgb7 | ↑ | 1273 | 2356 | 4276 | 3097 | C |
| Itga4 | ↑ | 96 | 274 | 42 | 76 | C |
| PTGER4 | ↓ | 650 | 221 | 1628 | 1090 | D |
| EGR2 | ↓ | 1941 | 655 | 143 | 122* | F |
| IEL proinflammatory | ||||||
| CD7 | ↑ | 76* | 58* | 216 | 1945 | E |
| BCL2L13 | ↑ | 258 | 242 | 197 | 441 | E |
| STAT3 | ↑ | 2033 | 1807 | 184 | 1107 | E |
| LPL and IEL anti-inflammatory | ||||||
| CST7 | ↑ | 70 | 468 | 725 | 1197 | A |
| Areg | ↑ | 274 | 488 | 71 | 530 | A |
| Nrp-1 | ↑ | 25* | 87 | 69* | 269 | A |
| IL-10 | ↑ | 288 | 745 | 144 | 713 | A |
| IFN-γ | ↓ | 179 | 20 | 730 | 143 | B |
| IL-7r | ↓ | 2430 | 567 | 2318 | 620 | B |
| LPL anti-inflammatory | ||||||
| Tnfrsf18/GITR | ↑ | 2384 | 7324 | 669 | 772 | C |
| LT-β | ↓ | 2113 | 358 | 1805 | 1695 | D |
| CCR5 | ↓ | 4212 | 1928 | 877 | 981 | D |
| IL-17 | ↓ | 867 | 298 | 256 | 377 | D |
| ICOS | ↓ | 1696 | 562 | 169 | 126 | D |
| IEL anti-inflammatory | ||||||
| ANXA1 | ↑ | 28* | 24* | 69* | 233 | E |
| CCL3 | ↓ | 357 | 485 | 1256 | 649 | F |
| CCR7 | ↓ | 329 | 309 | 1215 | 455 | F |
| IL-6rα | ↓ | 177 | 159 | 653 | 209 | F |
| ICAM1 | ↓ | 126 | 77 | 190 | 65* | F |
| LPL and/or IEL pro-/anti-inflammatory | ||||||
| PD1 | ↑ | 349 | 1446 | 87* | 247 | A |
| KLRG1 | ↑ | 194 | 380 | 77 | 78 | C |
| CCL5 | ↓ | 18622 | 15975 | 3550 | 1424 | D |
| Lag3 | ↑ | 69* | 36* | 45* | 388 | E |
| Tnfrsf4/OX40 | ↑ | 1386 | 5804 | 398 | 1494 | A |