Parameter (range) | Control | rAS3(0) | rAS3(0/3) | rScr(0) | rAS3(3) | rScr(3) |
---|---|---|---|---|---|---|
Abbreviations indicate the different treatment regimes as follows: rAS3, CD40 antisense ODN; rScr, scrambled control ODN; 0, treated at four hours prior to colitis induction on day 0; 3, treated on the third day post colitis induction. | ||||||
Values are mean (SD) score values rounded to one decimal. | ||||||
**p<0.01 versus control. | ||||||
Diarrhoea (0–2) | 0.1 (0.4) | 0.0 (0.0) | 0.0 (0.0) | 0.4 (0.5) | 0.2 (0.4) | 0.3 (0.5) |
General condition (0–1) | 0.3 (0.3) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 0.3 (0.5) |
Adhesions (0–3) | 2.1 (0.6) | 1.0 (0.5)** | 1.3 (1.0) | 2.1 (0.7) | 1.3 (1.0) | 2.0 (0.6) |
Perforation (0–1) | 0.3 (0.5) | 0.0 (0.0) | 0.3 (0.5) | 0.4 (0.5) | 0.2 (0.4)** | 0.8 (0.4) |
Necrosis (0–4) | 2.9 (0.6) | 1.3 (1.3)** | 1.8 (0.8)** | 3.4 (0.5) | 1.8 (0.8) | 2.7 (0.8) |
Ulceration (0–4) | 3.6 (0.5) | 2.5 (0.5)** | 2.3 (0.5)** | 3.9 (0.4) | 1.7 (0.8)** | 3.7 (0.8) |
Oedema (0–1) | 1.0 (0.0) | 1.0 (0.0) | 0.8 (0.4) | 1.0 (0.0) | 0.8 (0.4) | 1.0 (0.0) |
Megacolon (0–1) | 0.3 (0.5) | 0.1 (0.4) | 0.0 (0.0) | 0.3 (0.5) | 0.0 (0.0) | 0.2 (0.4) |
Total score | 10.6 (2.3) | 5.9 (2.2)** | 6.7 (2.6)** | 11.6 (2.4) | 6.0 (3.0)** | 11.0 (2.9) |
No of animals | 8 | 8 | 6 | 7 | 6 | 6 |