Relief of overall IBS symptoms and abdominal discomfort/pain: 50% rule
| First treatment | Repeated treatment* | |||
|---|---|---|---|---|
| Tegaserod (n = 2135) | Placebo (n = 525) | Tegaserod (n = 488) | Placebo (n = 495) | |
| *Includes only first treatment tegaserod patients who received repeated treatment. | ||||
| NNT, numbers needed to treat.17 | ||||
| Overall IBS symptoms, responder rate | 50.5% | 39.8% | 60.5% | 42.8% |
| Treatment difference (95% CI) | 10.6% (6.0–15.1) | 17.0% (11.2–22.7) | ||
| p Value | <0.0001 | <0.0001 | ||
| NNT | 9.4 | 5.9 | ||
| Abdominal discomfort/pain, responder rate | 47.8% | 38.7% | 58.8% | 38.8% |
| Treatment difference (95% CI) | 9.0% (4.5–13.5) | 19.9% (14.2–25.7) | ||
| p Value | 0.0002 | <0.0001 | ||
| NNT | 11.1 | 5.0 | ||