Clinical features and outcomes of PSC-IBD (cases) and controls with CUC
| PSC-IBD (n = 71) | Comparison CUC (n = 142) | |
|---|---|---|
| PSC-IBD, inflammatory bowel disease associated with primary sclerosing cholangitis; CUC, chronic ulcerative colitis; CRN, colorectal neoplasia; IPAA, ileal pouch-anal anastomosis; NA, not applicable. | ||
| Demographics and clinical features | ||
| Males (n (%)) | 46 (65%) | 92 (65%) |
| Age at IBD diagnosis (y) (median (range)) | 32 (9–73) | 28 (6–80) |
| Age at PSC diagnosis (y) (median (range)) | 42 (10–71) | NA |
| Pancolitis (n (%)) | 62 (87%) | 76 (54%) |
| Rectal sparing (n (%)) | 37 (52%) | 8 (6%) |
| Ileitis (n (%)) | 23/45 (51%) | 10 (7%) |
| Outcomes | ||
| CRN total (n (%)) | 18 (25%) | 15 (11%) |
| Low grade dysplasia (n (%)) | 8 (11%) | 7 (5%) |
| High grade dysplasia (n (%)) | 3 (4%) | 4 (3%) |
| Colorectal cancer (n (%)) | 7 (10%) | 4 (3%) |
| IBD diagnosis to CRN (y) (median (range) interval) | 12.7 (0.3–41) | 12.1 (1 day–5.8) |
| PSC diagnosis to CRN (y) (median (range) interval) | 4.9 (0.03–20) | NA |
| Surgery (n (%)) | 31 (28%) | 66 (46%) |
| IPAA (n (%)) | 14 (13%) | 43 (30%) |
| Brooke ileostomy (n (%)) | 5 (7%) | 21 (15%) |
| Ileorectal anastomosis (n (%)) | 7 (6%) | 0 (0%) |
| Pouchitis (n (%)) | 10/14 (71%) | 13/30 (30%) |
| Stomal varices (n (%)) | 2/5 (40%) | 0 (0%) |