Table 1

Fifty eight genes differentially expressed more than threefold (p<0.01), comparing normal mucosa from the caecum to that of the sigmoid or rectosigmoid

Probe set ID	Gene name	Symbol	UG cluster	Cyto band	Ncae med†	Nsig med‡	FC§	p Value¶
*Twelve of the 58 genes showed fold changes more than threefold.
†Ncae med, median derived from “signal” of 10 normal mucosae of the caecum.
‡Nsig med, median derived from “signal” of 10 normal mucosae of the sigmoid or rectosigmoid.
§FC, fold change, corresponding to the “signal ratio” of Nsig med/Ncae med, was calculated from the “signal log ratio”.
¶p value, probability that a variant would assume a value greater than or equal to the observed value strictly by chance.
UG cluster, UniGene cluster (http://www.ncbi.nlm.nih.gov/UniGene).
D13897_rna2_at	DNA peptide YY		Hs.169249	17q21.1	54	103	1.9	0.002
D14662_at	Antioxidant protein 2 (non-selenium glutathione peroxidase, acidic calcium independent phospholipase A2)	KIAA0106	Hs.120	1q24.1	471	918	2.0	0.005
D37931_at	Ribonuclease, RNase A family, 4	RNASE4	Hs.283749	14	214	337	1.6	0.001
D42043_at	KIAA0084 protein	KIAA0084	Hs.79123	3p24.3	220	142	−1.5	0.003
D84454_at	Solute carrier family 35 (UDP-galactose transporter), member 2	SLC35A2	Hs.21899	Xp11.23	152	247	1.6	0.001
HG1067-HT1067_r_at	Mucin (Gb:M22406)				196	479	2.4	0.001
HG2348-HT2444_s_at	Peptide Yy		Hs.169249		284	575	2.0	0.007
HG273-HT273_s_at	Fibrinogen A alpha polypeptide alt. splice 3 E*		Hs.351593	4q28	37	136	3.7	0.007
J03600_at	Arachidonate 5-lipoxygenase	ALOX5	Hs.89499	10q11.2	92	51	−1.8	0.006
J04164_at	Interferon induced transmembrane protein 1 (9–27)	IFITM1	Hs.146360	11	1494	963	−1.6	0.007
J04809_rna1_at	Cytosolic adenylate kinase (AK1) gene .		Hs.76240	9q34.1	75	116	1.5	0.003
J05036_s_at	Cathepsin E*	CTSE	Hs.1355	1q31	39	138	3.5	0.002
J05582_s_at	Mucin 1, transmembrane	MUC1	Hs.89603	1q21	586	899	1.5	0.005
K02765_at	Complement component 3	C3	Hs.284394	19p13.3	472	216	−2.2	0.007
L42379_at	Quiescin Q6	QSCN6	Hs.77266	1q24	529	1150	2.2	0.000
L77701_at	COX17 (yeast) homologue, cytochrome c oxidase assembly protein	COX17	Hs.16297	3q13.32	270	429	1.6	0.003
M11433_at	Retinol binding protein 1, cellular	RBP1	Hs.101850	3q23	54	25	−2.1	0.008
M12529_at	Apolipoprotein E	APOE	Hs.169401	19q13.2	922	489	−1.9	0.007
M16364_s_at	Creatine kinase, brain*	CKB	Hs.173724	14q32	614	2300	3.7	0.008
M16938_s_at	Homeo box C6	HOXC6	Hs.820	12q12	55	27	−2.0	0.002
M27281_at	Vascular endothelial growth factor	VEGF	Hs.73793	6p12	42	14	−2.1	0.002
M36341_at	ADP-ribosylation factor 4	ARF4	Hs.75290	3p21.2	693	1086	1.6	0.005
M77144_rna1_at	3-Beta-hydroxysteroid dehydrogenase*		Hs.825	1p13.1	109	18	−5.4	0.005
M80244_at	Solute carrier family 7, member 5	SLC7A5	Hs.184601	16q24.3	129	63	−2.0	0.002
M84424_at	Cathepsin E (CTSE) gene				17	53	2.7	0.005
M86849_at	Gap junction protein, beta 2, 26kD (connexin 26)	GJB2	Hs.5566	13q11	89	56	−1.6	0.007
M97925_rna1_at	Defensin 5*		Hs.72887	8pter-p21	215	35	−6.1	0.002
M98539_at	Prostaglandin D2 synthase gene				569	221	−2.6	0.001
S80562_at	Calponin 3, acidic	CNN3	Hs.194662	1p22	127	79	−1.6	0.001
U03057_at	Actin bundling protein (HSN)	SNL	Hs.118400	7p22	312	200	−1.6	0.002
U24576_at	LIM domain only 4; breast tumour autoantigen complete sequence	LMO4	Hs.3844	1p22.3	97	52	−1.9	0.007
U33632_at	Potassium channel, subfamily K, member 1 (TWIK-1)	KCNK1	Hs.79351	1q42	52	87	1.7	0.002
U50553_at	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	DDX3	Hs.147916	Xp11.3	63	42	−1.5	0.008
U61262_at	Neogenin (chicken) homolog 1	NEO1	Hs.90408	15q22.3	139	210	1.5	0.003
U66661_at	Gamma-aminobutyric acid (GABA) A receptor, epsilon	GABRE	Hs.22785	Xq28	60	32	−1.9	0.007
U73514_at	Hydroxyacyl-coenzyme A dehydrogenase, type II	HADH2	Hs.171280	Xp11.2	298	462	1.6	0.009
U75679_at	Stem-loop (histone) binding protein	SLBP	Hs.75257	4p16.3	65	43	−1.5	0.007
U81599_at	Homeo box B13*	HOXB13	Hs.66731	17q21.2	33	240	7.2	0.001
U90065_s_at	Potassium channel, subfamily K, member 1 (TWIK-1)	KCNK1	Hs.79351	1q42	160	293	1.8	0.002
U90911_at	Clone 23652 sequence		Hs.171807	–	463	304	−1.5	0.000
X00371_rna1_at	Myoglobin gene (exon 1)		Hs.118836	22q13.1	213	108	−2.0	0.004
X52003_at	pS2 protein; trefoil factor 1*	TFF1	Hs.1406	21q22.3	313	2413	7.7	0.000
X59770_at	Interleukin 1 receptor, type II	IL1R2	Hs.25333	2q12	160	427	2.7	0.001
X61118_rna1_at	LIM domain only 2 (rhombotin-like 1) TTG-2	LMO2	Hs.184585	11p13	63	38	−1.7	0.005
X63187_at	WAP four-disulfide core domain 2*	WFDC2	Hs.2719	20q12	134	714	5.3	0.002
X64072_s_at	Integrin, beta 2 (antigen CD18), (mac-1)	ITGB2	Hs.83968	21q22.3	123	64	−1.9	0.005
X65614_at	S100 calcium-binding protein P	S100P	Hs.2962	4p16	170	1293	7.6	0.001
X74570_at	Sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)*	SIAT4C	Hs.75268	11q23	87	486	5.6	0.001
X75042_at	v-rel avian reticuloendotheliosis viral oncogene homolog	REL	Hs.44313	2p13–p12	64	33	−2.0	0.005
X78924_at	Zinc finger protein 266	ZNF266	Hs.118281	19	43	24	−1.9	0.002
X85545_at	Protein kinase, X-linked	PRKX	Hs.147996	Xp22.3	39	24	−1.6	0.007
X87159_at	Sodium channel, non-voltage-gated 1, beta (Liddle syndrome)*	SCNN1B	Hs.37129	16p12.2	79	393	5.0	0.008
X97324_at	Adipose differentiation-related protein	ADFP	Hs.3416	9p21.3	194	112	−1.7	0.001
Y00503_at	Keratin 19	KRT19	Hs.182265	17q21	1422	2968	2.1	0.001
Y11251_at	Splicing factor, arginine/serine-rich 2, interacting protein	SFRS2IP	Hs.51957	12q12	69	41	−1.7	0.004
Z29090_at	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	PIK3CA	Hs.85701	3q26.3	33	18	−1.7	0.004
Z35278_at	Runt-related transcription factor 3; PEBP2aC1 acute myeloid leukaemia	RUNX3	Hs.170019	1p36	47	30	−1.6	0.008
Z48541_at	Protein tyrosine phosphatase, receptor type, O*	PTPRO	Hs.258609	12p13.3	19	61	3.0	0.008