Table 3

Forty two genes differentially expressed more than fourfold (p<0.01), comparing normal mucosa to Dukes’ B or C tumours from the sigmoid or rectosigmoid

Probe set ID	Gene name	Symbol	UG cluster	Cyto band	Nsig med*	IQ N†	Bsig med‡	IQ B	Csig med§	IQ C	Avg FC¶ NvB	Avg FC NvC
*Nsig med, median derived from “signal” of 10 normal mucosae of the sigmoid and rectosigmoid.
†IQ interquartile, difference between the 75th and 25th percentiles.
‡Bsig med, median derived from “signal” of eight Dukes’ B adenocarcinomas of the sigmoid and rectosigmoid.
§Csig med, median derived from “signal” of seven Dukes’ C adenocarcinomas of the sigmoid and rectosigmoid.
¶FC, fold change, corresponding to the “signal ratio” of Nsig med/Bsig med or Nsig med/Csig med, was calculated from the “signal log ratio”.
UG cluster, UniGene cluster (http://www.ncbi.nlm.nih.gov/UniGene).
D84239_at	Fc fragment of IgG binding protein	FCGBP	Hs.111732	19q13.1	2819	726	233	525	171	408	−21.0	−23.4
HG2981-HT3125	Epican Alt. Splice 1				13	7	58	53	75	43	4.3	5.6
J03910_rna1_at	Metallothionein-IG gene	MT1G	Hs.173451	16q13	2252	1934	409	581	148	105	−6.9	−12.3
J03915_s_at	Chromogranin A	CHGA	Hs.172216	14q32	448	153	62	62	41	20	−5.0	−6.1
J04040_at	Glucagon	GCG	Hs.1460	2q36	314	514	27	35	11	6	−8.7	−15.5
J04093_s_at	UDP glycosyltransferase 1 family	UGT1A6	Hs.284239	2q37	204	78	41	34	35	18	−4.0	−5.2
J04152_rna1	M1S1 gene		Hs.23582	1p32–p31	6	11	66	30	144	509	6.9	19.0
J05257_at	MDP4 MDP7 microsomal dipeptidase	DPEP1	Hs.109	16q24.3	26	10	847	790	388	366	20.1	7.9
L10373_at	(Clone CCG-B7) sequence		Hs.82749	Xq11	310	91	74	77	61	27	−4.6	−5.6
L10955_cds1	Carbonic anhydrase IV gene	CAIV			1186	365	194	195	30	19	−7.2	−32.7
L11708_at	Hydroxysteroid (17-beta) dehydrogenase 2	HSD17B2	Hs.155109	16q24.1	414	71	41	65	22	10	−5.9	−6.4
L12760_s_at	Phosphoenolpyruvate carboxykinase 1	PCK1	Hs.1872	20q13.31	755	566	106	145	40	31	−4.2	−11.0
L21998_at	Mucin 2, intestinal/tracheal	MUC2	Hs.315	11p15.5	4189	1013	1175	2355	243	206	−4.1	−14.8
L22524_s_at	Matrilysin gene				5	5	37	17	570	683	6.1	83.2
L76465_at	Hydroxyprostaglandin dehydrogenase 15	HPGD	Hs.77348	4q34–q35	213	48	61	45	21	22	−4.5	−7.7
M12963_s_at	Alcohol dehydrogenase 1A (class I), alpha	ADH1A	Hs.73843	4q21–q23	1724	645	260	649	59	69	−7.1	−38.8
M14758_at	ATP binding cassette, sub-family B	ABCB1	Hs.21330	7q21.1	162	66	37	60	33	28	−4.1	−6.1
M16364_s_at	Creatine kinase-B	CKB	Hs.173724	14q32	2300	720	501	693	314	275	−4.8	−13.2
M16801_at	Nuclear receptor subfamily 3, group C	NR3C2	Hs.1790	4q31.1	161	34	32	26	13	2	−4.0	−10.3
M18079_at	Fatty acid binding protein 2, intestinal	FABP2	Hs.282265	4q28–q31	184	126	31	23	20	18	−4.9	−10.2
M60047_at	Heparin binding growth factor binding protein	HBP17	Hs.1690	4p16–p15	143	99	33	32	28	12	−4.4	−4.8
M77349_at	Transforming growth factor, beta induced	TGFBI	Hs.118787	5q31	307	145	1735	787	2618	1643	5.3	8.0
M87860_at	S-lac lectin L-14-II (LGALS2) gene				232	129	40	39	12	18	−5.3	−7.4
M97496_at	Guanylate cyclase activator 2A (guanylin)	GUCA2A	Hs.778	1p35–p34	1931	279	147	150	62	47	−15.8	−44.5
U14528_at	DTD sulfate transporter	SLC26A2	Hs.29981	5q31–q34	620	410	137	182	23	12	−4.3	−20.1
U17077_at	BENE protein	BENE	Hs.185055	2q13	1499	544	214	108	207	212	−4.3	−6.2
U70663_at	Kruppel-like factor 4, hEZF	KLF4	Hs.7934	9q31	605	362	76	98	44	56	−6.2	−8.8
X52001_at	Endothelin 3	EDN3	Hs.1408	20q13.2	100	44	34	32	6	7	−4.6	−16.1
X53800_s_at	GRO3 oncogene	GRO3	Hs.89690	4q21	21	13	73	49	75	95	5.3	5.0
X54489_rna1_at	(MGSA)	MGSA	Hs.789	4q21	56	19	262	235	484	601	7.8	8.4
X54925_at	(Interstitial collagenase)	MMP1	Hs.83169	11q22.3	12	7	129	73	945	1041	7.3	31.8
X57579_s_at	Inhibin, beta A (activin A)	INHBA	Hs.727	7p15–p13	7	9	60	68	433	332	5.1	26.7
X59766_at	Alpha-2-glycoprotein 1, zinc	AZGP1	Hs.71	7q22.1	15	19	333	125	114	83	18.8	4.4
X59770_at	Interleukin 1 receptor, type II	IL1R2	Hs.25333	2q12–q22	427	185	48	25	65	42	−6.4	−4.5
X63597_at	Sucrase-isomaltase	SI	Hs.2996	3q25.2	37	36	12	13	3	4	−8.0	−14.1
X63629_at	Cadherin 3, type 1, P-cadherin (placental)	CDH3	Hs.2877	16q22	14	8	214	76	134	146	11.2	6.6
X73501_at	Cytokeratin 20	KRT20	Hs.84905	17q21.1	1553	635	185	130	107	110	−5.5	−12.0
X87159_at	Sodium channel, nonvoltage-gated 1	SCNN1B	Hs.37129	16p12.2	393	180	29	51	10	5	−8.3	−22.1
X98311_at	Carcinoembryonic antigen-related	CEACAM7	Hs.74466	19q13.2	3817	1389	462	475	145	114	−4.1	−16.3
Y00339_s_at	Carbonic anhydrase II (EC 4.2.1.1)	CA2	Hs.155097	8q22	1096	465	58	112	28	12	−20.8	−27.4
Y00787_s_at	Interleukin 8/MDNCF	IL8	Hs.624	4q13–q21	53	260	614	326	1794	2320	5.4	15.5
Z70295_at	GCAP-II (uroguanylin)	GUCA2B	Hs.32966	1p34–p33	453	64	9	5	7	3	−25.0	−39.0