Folic acid (n = 15) | Placebo (n = 16) | ||
---|---|---|---|
MTHFR, methylenetetrahydrofolate reductase; MS, methionine synthase. | |||
Values are arithmetic means (SD) for age, folate intake, and serum vitamin B12, median (range) for body mass index, and number (%) for alcohol intake, smoking, and genotype. | |||
**p<0.01 compared with the folic acid group. | |||
†n = 15. | |||
n (M/F) | 7/8 | 8/8 | |
Age (y) | 63.9 (11.9) | 63.8 (9.7) | |
Body mass index (kg/m2) | 25.3 (19.8–49.4) | 25.0 (19.8–36.8) | |
Folate intake (μg/day) | 341 (118) | 368 (156)† | |
Serum vitamin B12 (ng/l) | 446 (235) | 461 (235) | |
Alcohol intake (g/day) | |||
Lower third (<2) | 7 (47) | 3 (19) | |
Middle third (2–37) | 5 (33) | 6 (38) | |
Upper third (>37) | 3 (20) | 7 (44) | |
Smoking | |||
Current smoker | 1 (7) | 8 (50)** | |
Non-smoker | 14 (93) | 8 (50) | |
MTHFR 677C→T genotype | |||
CC | 10 (67) | 9 (56) | |
CT | 5 (33) | 5 (31) | |
TT | 0 (0) | 2 (13) | |
MS 2756A→G genotype | |||
AA | 10 (67) | 6 (38) | |
AG | 5 (33) | 9 (56) | |
GG | 0 (0) | 1 (6) |