Epidermal growth factor receptor related protein (ERRP) expression in non-malignant gastric mucosa, dysplasia, and gastric cancers
| No of ERRP positive specimens | ERRP expression score (mean (SEM)) | |
|---|---|---|
| Kruskal-Wallis test showed an inverse relationship between ERRP expression and gastric carcinoma differentiation. In gastric cancers there was a marked decrease in ERRP expression with 31 of 47 (66%) specimens exhibiting negative staining for ERRP. In ERRP positively stained gastric cancer specimens (34% of all cancer specimens), ERRP was localised to the membrane or membrane and cytoplasm. | ||
| Non-malignant mucosa (n = 47) | 31 (66%) | 2.9 (0.3) |
| Dysplasia (n = 10) | 7 (70%) | 3.2 (0.9) |
| Total gastric cancer (n = 47) | 16 (34%) | 1.4 (0.3) |
| Well differentiated carcinoma (n = 10) | 6 (60%) | 2.6 (0.6) |
| Moderately differentiated carcinoma (n = 10) | 2 (20%) | 0.9 (0.6) |
| Poorly differentiated carcinoma (n = 12) | 3 (25%) | 1.0 (0.5) |
| Signet ring cell carcinoma (n = 15) | 5 (33%) | 1.3 (0.5) |