Characteristics of the human gastric cancer cell lines used in this study
| Cell line | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KatoIII | JRST | MKN1 | MKN28 | MKN45 | MKN74 | NUGC3 | NUGC4 | SNU1 | SNU638 | GT3TKB | HGC27 | |
| *AC, adenocarcinoma; ASC, adenosquamous carcinoma; DA, differentiated adenocarcinoma; PA, poorly differentiated adenocarcinoma; SRC, signet ring cell carcinoma; UDA, undifferentiated adenocarcinoma. | ||||||||||||
| †mt, mutant-type; WT, wild-type; ?, no information. | ||||||||||||
| +, strong expression; ±, weak expression; −, no expression. | ||||||||||||
| Histological type* | SRC | SRC | ASC | DA | UDA | DA | PDA | SRC | AC | AC | AC | UDA |
| p53† | mt(loss) | ? | mt | mt | WT/mt | mt | mt | WT | WT | mt | ? | ? |
| IGF-I | + | + | − | − | + | + | − | − | ± | ± | − | − |
| IGF-II | − | ± | + | ± | + | + | ± | + | ± | ± | − | + |
| IGF-Ir | + | + | + | + | + | + | + | + | + | + | − | ± |
| IGF-2r | + | + | + | + | + | + | + | + | ± | + | + | ± |