Summary of relative caspase-3 activity induced by 5% ethanol
| Cell line | Adenovirus/inhibitors | Relative caspase-3 activity (%) | ||
|---|---|---|---|---|
| No stimulation | 5% ethanol | p Value* | ||
| Values are mean (SEM). | ||||
| Ad-LacZ, control (adenovirus expressing β-galactosidase); Ad-IGF-Ir/482st, adenoviruses expressing truncated IGF-Ir of 482 amino acids long; Ad-IGF-Ir/950st, adenoviruses expressing truncated IGF-Ir of 950 amino acids long. | ||||
| *Compared with cells infected with Ad-LacZ stimulated with 5% ethanol. | ||||
| MKN45 | Ad-LacZ | 1.00 (0.01) | 1.38 (0.03) | |
| Ad-IGF-Ir/482st | 1.23 (0.04) | 1.83 (0.09)* | 0.0002* | |
| Ad-IGF-Ir/950st | 1.21 (0.07) | 1.78 (0.05)* | 0.0011* | |
| MKN74 | Ad-LacZ | 1.00 (0.03) | 1.72 (0.02) | |
| Ad-IGF-Ir/950st | 1.26 (0.01) | 1.94 (0.02)* | 0.0064* | |
| MKN45 | Ad-LacZ without wortmannin | 1.00 (0.01) | 1.36 (0.04) | |
| Ad-LacZ with wortmannin | 1.53 (0.01) | 1.77 (0.02)* | 0.001* | |
| MKN45 | Ad-LacZ without PD98059 | 1.00 (0.02) | 1.52 (0.04) | |
| Ad-LacZ with PD98059 | 1.07 (0.01) | 1.63 (0.04)* | NS* | |
| MKN45 | Ad-LacZ without SB203580 | 1.00 (0.02) | 1.77 (0.05) | |
| Ad-LacZ with SB203580 | 1.09 (0.07) | 1.92 (0.01)* | NS* | |